GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs1577917 | 1 | rs35760725 | chr6:86648985 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -7.62 | 1.9E-11 | Response to antipsychotic treatment |
| THYM | cis | rs1577917 | 1 | rs35761942 | chr6:86629504 | SNHG5 | chr6:86386726-86388451:- | -0.61 | -7.35 | 6.78E-11 | Response to antipsychotic treatment |
| THYM | cis | rs1577917 | 1 | rs35797755 | chr6:86706554 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -6.89 | 5.95E-10 | Response to antipsychotic treatment |
| THYM | cis | rs2243480 | 1 | rs35820085 | chr7:65442758 | CCT6P1 | chr7:65216092-65228661:+ | 0.65 | 5.32 | 6.97E-7 | Diabetic kidney disease |
| THYM | cis | rs2243480 | 1 | rs35825738 | chr7:65318027 | CCT6P1 | chr7:65216092-65228661:+ | 0.64 | 4.78 | 6.3E-6 | Diabetic kidney disease |
| THYM | cis | rs3772130 | 1 | rs35988617 | chr3:121432902 | IQCB1 | chr3:121488610-121553926:- | 0.45 | 4.25 | 5.03E-5 | Cognitive performance |
| THYM | cis | rs2243480 | 1 | rs36033484 | chr7:65390558 | CCT6P1 | chr7:65216092-65228661:+ | 0.7 | 5.13 | 1.51E-6 | Diabetic kidney disease |
| THYM | cis | rs2243480 | 1 | rs36068983 | chr7:65408991 | CCT6P1 | chr7:65216092-65228661:+ | 0.62 | 5.13 | 1.51E-6 | Diabetic kidney disease |
| THYM | cis | rs1577917 | 1 | rs36096931 | chr6:86693134 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -6.89 | 5.95E-10 | Response to antipsychotic treatment |
| THYM | cis | rs60843830 | 1 | rs36216559 | chr2:262335 | SH3YL1 | chr2:218138-264810:- | -0.33 | -4.86 | 4.59E-6 | Spherical equivalent (joint main effects and education interaction) |
| THYM | cis | rs9457247 | 1 | rs364283 | chr6:167383750 | RNASET2 | chr6:167343008-167412795:- | -0.47 | -7.83 | 7.0E-12 | Crohn's disease |
| THYM | cis | rs9457247 | 1 | rs364451 | chr6:167384756 | RNASET2 | chr6:167343008-167412795:- | -0.45 | -7.53 | 2.89E-11 | Crohn's disease |
| THYM | cis | rs9457247 | 1 | rs365189 | chr6:167384545 | RNASET2 | chr6:167343008-167412795:- | -0.47 | -7.83 | 7.0E-12 | Crohn's disease |
| THYM | cis | rs3820928 | 1 | rs3731593 | chr2:227773924 | RHBDD1 | chr2:227700773-227861591:+ | -0.31 | -4.5 | 1.93E-5 | Pulmonary function |
| THYM | cis | rs3731714 | 1 | rs3731714 | chr2:202060820 | PPIL3 | chr2:201735680-201753999:- | 0.48 | 4.36 | 3.36E-5 | Trans fatty acid levels |